Research on HIFU actually began in the 1950s at Indiana University. In 1994, the first human prostate cancer study was done by Dr. Marberger and Madersbacher at the Univ. of Vienna in Austria using the Sonablate® 200 treating 29 human prostates in vivo shortly before performing a radical prostatectomy. The goal was to see if the energy delivered was enough to destroy the desired tissue. Study found that treatment could be performed safely and could be repeated. In 1995, a study done at IU showed that the whole prostate could be treated without damaging the prostate capsule or the rectal wall. In 1999, Dr. Toyaki Uchida began treating patients using the Sonablate® 200. In 2001, Sonablate® 500 receives CE mark from Europe and the first patient in the study was treated at IU by Dr. M. Koch. In 2004, USHIFU was created and has placed machines in Canada, Mexico, Costa Rica, South Africa and the Caribbean. The first Sonablate® 500 arrived to Puerto Vallarta on August, 2004, the training and trials were done during 2004, using the system to treat BPH and prostate cancer since 2005. Currently there are nearly 100 Sonablate® 500 HIFU centers worldwide on six continents. There are over 150 physicians using the Sonablate® 500 worldwide and over 5,000 total procedures have been completed with the Sonablate®. In the HIFU MX center in Puerto Vallarta, a total of 350 patients have received treatment with HIFU. 
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